Yes! I've carried Kimbers, Glocks, S&Ws, XDs, etc. I always had an issue with pants sag, so I pulled my belt so tight it would be uncomfortable or bunched up my jeans. I got this 642.....holy shit! This thing is like carrying nothing. It's so light I come in from the wild and totally forget I have it on. Recently I got bored carrying it and tried a Glock 30. That lasted one hour and back to the 642 I went.