Yes! I've carried Kimbers, Glocks, S&Ws, XDs, etc.  I always had an issue with pants sag, so I pulled my belt so tight it would be uncomfortable or bunched up my jeans.  I got this 642.....holy shit!  This thing is like carrying nothing.  It's so light I come in from the wild and totally forget I have it on. Recently I got bored carrying it and tried a Glock 30.  That lasted one hour and back to the 642 I went.