Based on places Ive spent a lot of time in I would pick San Diego, Cali as my first choice. It just has everything I could ever want in a city. I like to call it heaven when I speak of it.
My second choice would be Austin, Texas. As much as I hate the state of Texas, Austin is where it is at. It also has everything I need in a big city but it lands second to SD because SD is the shiznit and its on the West Coast...