I got my hands on the copy for the 360. I must say this game has a lot of things I wished fallout 3 had. Everything is the same from the past game with some few added features. All guns have iron sights. You can still use VATS if you want. I like that you can sneak attack while in iron sights if you are hidding. Also the ammo changes. You have normal ammo, armor piercing and, hollow points. This ammo must be loaded to change so you got to be careful because each reload degrades your weapon condition. So far the ammo I have found is 22LR, .357, .9mm, .45, and .556. You can buy addons to your guns like silencers and scopes.
The other thing I love is the crafting aspect of the game. Remember all that useless stuff you would find in boxes? Empty bottles, syringes, medical tubing? Stuff like this can be used to make stimpacks, other medical healing items, and also edible food. I was able to steal corn from a corn field so far. Also I found a small patch of jalapeno peppers I could steal. You can use these for a small 1+ HP gain or save them to craft something more powerful. If you find a campfire in the wasteland you can use it to craft food.
Also you have a weapons bench and a ammo press. Both of these allow you to craft. You can craft new weapons and also addons to your weapons. With the press you can use it to make ammo or strip down ammo for parts. You must find empty shells and gun power to make ammo. Another neat thing is sometimes you collect your empty shells after shooting a gun and save them.
Fuck CR I am going to go play this game more. A couple hours last night was not enough. ;)