When mileage gets UP THERE, past the normal realm of everyday use (15K / year?) it can be cause for concern. I dont give a flying fack if you drive it all highway from OH to FL 23 times a year... that is a LOT of work / use for a vehicle. Price should reflect mileage. I know someone driving 2K / year can neglect or beat up a car just as easily, but everything is relative... at least mileage is a good factor you can tangibly look at.
That's why I bought a Toyota lol. Sure its currently low mileage, but there are plenty of high mileage examples out there with a proven track record. Add in that mine is meticulously maintained, once I hit the high mileage, I will have no worries.
That is the good thing about us car-guys.... We can keep cars for-freakin-ever and feel confident even when were turning over odometers ...
Main point is unless you know exactly who owned a vehicle or how it has been kept, use mileage to your advantage... assume its been beat on for every single one, and price accordingly