From the replies so far, I don't think you could use any of my advice or local connections.
One thing, get off of Fremont street and down to the strip. It will look 100x different than the last time you saw it, and have 100x more attractive people to look at.
If you are looking for the over 40' with the wife type of experience, make sure you see a show (look for a deal on tickets before you land) and eat one REALLY good meal there. Its the most highly concentrated are of 5 star restaurants on this side of the planet, and depending on the year, the world. Take advantage.
Also-go to the LINQ, and right the tallest Ferris wheel on the planet. You may be the first on CR to do so
http://www.thelinq.com/