That is definitely a long way to go on the 650 but shouldn't be too bad at the very least buy yourself a cramp buster or you might be able to find a vista cruise that will fit your bike.... the nice part of long highway trips on a bike is you have to stop for fuel often drink plenty of fluids and walk around on your gas stops if you have frame sliders on your bike they make a good place to rest your feet and stretch your legs... you could pick up a set of foam grips they have ones that slip over your existing grips they would help absorb some of the vibration