Depends how long and how steep the grade. On a ride earlier this year, UP and I got detoured onto a shitty gravel (larger stones) road with steep incline and an even steeper decline. It was pretty hectic. Street tires are not meant for those conditions. We did the decline under 5mph, with little to no traction. At one point, I had both brakes locked and was still sliding down the hill out of control. My bike easily could of wound up on it's side. I've ridden dirt bikes in much worse conditions than that without issue, but I wouldn't do it again on street tires.