25E sounds great. Looking at the map I am thinking of jumping off 75 even sooner near richmond onto 421, and then taking 11 over to 25E: https://maps.google.com/maps?saddr=Cincinnati,+OH&daddr=37.7463254,-84.2671595+to:37.4841312,-84.1046241+to:manchester,+ky+to:Middlesboro,+KY+to:805+Foothills+Mall+Drive,+Maryville,+TN+37801&hl=en&ll=37.426888,-84.105835&spn=3.528753,7.13562&sll=37.278424,-83.583984&sspn=3.535735,7.13562&geocode=FY6qVAId7HL2-in5ITjesVFAiDEXk8Dki377aQ%3BFZX2PwIdaS_6-imBj6zjBgJDiDG-uSyokSSdTA%3BFWP2OwIdUKr8-ikbXatlriJDiDH5Ekgh_XuGqQ%3BFaXrNgIdOOUB-ymrpKbSWU1DiDGIzW3dyqpMsg%3BFRmVLgIdE58C-ykLxWVMKoVciDGa0zmKWK3FHg%3BFZOJIQId3EP--ilt5uUgF55eiDGVeoQfv5-MWA&mra=ls&via=1,2&t=m&z=8 Anyone familiar with 421?