I think its even up to 8 devices. I just got one for my basement devices and set it up in like 20 mins while playing Halo. It's great because I programmed it for my Samsung TV, Onkyo reciever, Xbox which is one corner and in the other corner have my Vizio tv and roku all on one remote. It's glorious
Setup is definitely cake. Do it all on the computer and all you need are the model numbers of your devices