food/water/plan is first on your list for sure. You obviously cant rely on stores because looting is there first thing to happen followed by home invasion. If you have your supplies all in order its time to make sure you weapon is ready and ammo is easy to access. I always gauge munitions on the heavy side and like Scott said most of that weight is easier carried in a vest or hung carrying pack/ leg drop/ vest.
Now the hard question, how do you get from were you are to were you want to be. Are the roads clogged? floaded? 4WD available? Is the vehicle reliable? gas availability?
Most cases hoofing it is the best idea to keep concealed and quiet but driving also keeps you from tiring yourself out faster and lets you cover distances faster. I honestly plan on walking out of Columbus because If I would see a car I would think they have something to hide and it would be my first target.
My largest concern if there is civil unrest is what do you do if the military decides to enact marshal law or keep us quarentined (sp?) to our homes? Obviously you do not want to be caught outside or away from your home but on the same token they will not be able to watch every home/ neighborhood from looters or whatever might be out there.