Carry what's comfortable. Something is better than nothing. I have .45s, 9mms, .380s, .38 specials, and a few .22s. Ideally, I'd like to carry my Glock 26, but it's still bulky. I find myself carrying the little S&W 642 .38 Special most often because its comfortable. And so I carry. Don't get caught up in the .45 vs .380 vs 9mm debate. Yes, a .45 stops a person better, but not one sitting in your safe at home.