I had a cannondale R500 but I really hated the 'race stance'
I sold it and got this Giant FCR2 hybrid, haven't looked back since, I love it. Carbon Fiber forks are FTW. Also has the SRAM shifters where the up shift and downshift are both on the underside of the handlebar for maximum control. These are MTB shifters but Giant put them on the FCR2, it took some time to get used to but I really like them.
http://i27.photobucket.com/albums/c192/BertoBizkit/DSC03401.jpg
I ride with lycra, if I am doing a 30 + mile ride i'll ride with just the lycra. If its a shorter ride i'll throw some shorts over. Say what you want but the seams in the shorts will eventually rub you raw. The lycra is designed to be seamless where it counts. Also, it breathes awesome.