Eh, I'd be hard pressed to say that an inline 4 is like a 2 stroke, and there are lots of different V-twins. Assuming your talking about a real V-Twin (liquid cooled, 4 valves per cylinder, 10k+ redline) it all depends on what your comparing, Hell I can start my 'Bus off on a moderate incline just by slipping the clutch, it's got plenty of TQ at 2500rpms and I usually cruise around town around 2000 RPMS with no problems. Lets take a 1000cc Twin, and a 1000cc I4, the twin will have 2 x 500cc cylinders, while the I4 will have 4x250cc cylinders, and the twin usually has a longer stroke, longer stroke = more TQ at a lower given RPMs, it also means more rotating mass, therefore harder to spin fast due to the extra stress on components. There really isn't any advantage of one over the other, you just have to keep the R's on the I4 a little higher to produce the same TQ as the long stroke twin of the same displacement.