Your favorite upstairs tequila bar isn't there anymore - moved across the street. We go to Santa Fe for Xmas every year for the past 15 years and really like the area. Usually ride through here 1-2 tiems each summer too. Santa Fe is a great place to hit up, especially with your wife. Tons of really good New Mexican food, loads of art galleries, oldest city in the USA with some excellent old style architecture in the Square area. Good riding, mostly north of town. Check out the Valles Caldera off of Route 4 west of Los Alamos. Site of an ancient volcanic eruption. Loads of wildlife walking around and a really decent road to ride as well. Taos is close and you should check out the old Catholic church at Chimayo on the way up there. Nice casino - if you're into the whole gambling thing - just north of town at the Hilton Buffalo Thunder resort. Nice hotel as well with decent restaurants, etc. A better route might be a little more northern through Utah and Colorado with tons more to see. But it might be a bit longer as well if your final destination is San Diego.