I tiled my basement shower in my old house. My advice is don't do it. It looked great, but it was a maintenance nightmare. You can use the best grout, seal it over and over, and you're still going to get some mold/mildew in the grout lines. I used some fancy swimming pool grout, meant for tile under/above the water line and still had problems. I stopped uising that shower because I was sick of cleaning grout. If the drain location is the problem, move it. It's not that difficult. Drop in an nice 48" shower stall and be done with it Edit: http://www.johnbridge.com/articles/showers/tile-showers/