Way back on my CBR, I bought brand new pilot road 2's and within 50mi I got a nail in the rear tire. I plugged it myself with one of those kits you get in the auto store and put 5k miles on it before I sold the bike. I will say that the nail was dead center of the tire. If it was near the edges or if I had a very soft compound tire, I probably would replace the tire, You should be good with the PR4.