on a v8 aplication, i would go twins.
In order to flow enough air on a v8, a single turbo would be quite large, and would take time to spool up.
you can do it with a carb. You will need a rising rate fuel pressure regulator, and an electric fuel pump. You will need to plumb the perussure port on the regulator to the top part of your carb (before the throttle plates) otherwise you will not be getting any fuel into the carb (carbs usually only run about 4-5 psi fuel pressure) and the fuel bowls need to be at the same pressure as the air coming into the carb or else the pressureized air will prevent any fuel from flowing though the jets. You can run your primaries at a nomal mixture, and run your secondaries righ (youll probably only get into boost when you are getting into your secondaries anyways)
if you want, hit me up some night at krogers, or on im, ive done some research into this.