These are always fun threads. I say no. Sucks when it happens, but bike tires have very different forces twisting on them compared to car tires. If the nail broke a cord, you take a chance of the tire shredding. Then there is the chance of the plug working its way out at speed due to the twisting forces exerted on a bike tire. Flat tire at speed on a car, no big deal. Flat tire at speed on a bike, very big deal!