Q: Can high compression engines utilize nitrous oxide?
A: Absolutely. High or low compression ratios can work quite suitably with nitrous oxide provided the proper balance of nitrous and fuel enrichment is maintained. NOS kits are used in applications from relatively low compression stock type motors to Pro-Modifieds, which often exceed 15 to 1. Generally, the higher the compression ratio, the more ignition retard, as well as higher octane fuel, is required. For more specific information talk to one of our technicians.
this is right From Nitrous Oxide Systems website.
http://www.holley.com/HiOctn/TechServ/TechInfo/NOSTech5.html
compression makes power, regardless of your engine combination.
you have to have your air fuel mixture right and your timing down.
most people are scared of compression becuase you can't make mistakes and its always right out on the ragged edge, but with a good tune and a stout shortblock the skies the limit.